Nicotine itself is not addictive, but 電子煙 responsible for releasing dopamine, a neurotransmitter associated with pleasure and improvements in the brain, causing people to become addictive. Nicotine is a chemical found in a tobacco sheet, the main ingredient in cigarettes, which is said to cause addiction and disease in cigarette smokers (World Health Organization (WHO) ).
Nicotine mimics the activity of acetylcholine, a natural neurotransmitter in the central nervous system and the neuromuscular connection of skeletal muscles. Acetylcholine is responsible for irritability, leading to an increase in heart rate, activity and reaction time (Psychopharmacology (Berl). 1989; 97 (2): 257-61). Because acetylcholine and nicotine are chemically similar, they trigger the same cholinergic receptors in the brain. The nicotine-acetylcholine receptors consist of nerve endings that secrete dopamine when combined or bind to nicotine or acetylcholine. The receptors are similar to cups with precise sizes that correspond to a neurotransmitter molecule, such as acetylcholine.
The incision itself is lined with nerve endings (the ends of neurons). It is these nerve endings that secrete dopamine when the neurotransmitter acetylcholine binds to the cup-shaped receptors of acetylcholine (cholinergic receptors). The phenomenon of dopamine reinforcement and reward develops because dopamine, released by nerve endings, causes a sense of pleasure in the human brain. The reinforcement mechanism is triggered when the brain becomes dependent on the pleasure caused by dopamine released by cholinergic receptors. This means that the brain is constantly trying to take advantage of it. So what will happen in the case of cigarette smokers is that they will continue to smoke cigarettes, so nicotine from a cigarette can cause the release of dopamine in the brain, making them happy whenever they are.” (Nature Reviews Neuroscience 7, 967-975 (December 2006)).
When smokers first smoked cigarettes, only a few cholinergic receptors were available, because the natural action of acetylcholine requires only the normal number of receptors provided by nature to do its job. However, the increase in the concentration of available nicotine led to the fact that normal amounts of cholinergic receptors stopped responding to the presence of increased amounts of nicotine in cholinergic receptors. This desensitization causes the production or growth and development of more cholinergic receptors. These additional cholinergic receptors quickly lose sensitivity due to excess available nicotine. Such processes take place until a balance is reached. The balance is established when cigarette smokers decide how many cigarettes they smoke or smoke per day. At the moment, a fixed number of receivers are available to continue the dependency. Smokers usually say they smoke one or two bags a day. They said this is due to the number of receptors available for two packs of cigarettes a day.
The detrimental effect of all this is the fact that now available such a large number of cholinergic receptors and the need for nicotine. In this way, they can increase dopamine levels to please a cigarette smoker. This is why it is very difficult for cigarette smokers to quit. Therefore, the best way to quit smoking cigarettes is to gradually reduce the number of cigarettes smoked over a period of time.
In addition to the dopaminergic effect of nicotine, every time you smoke a cigarette, there is an increase in the pulse of nicotine. From a medical point of view, constantly artificially increasing the heart rate is also not a good idea. On the one hand, a constant increase in heart rate due to drugs such as nicotine can cause heart disease (WHO).
According to the World Health Organization, smoking leads to heart and lung diseases such as heart attacks, strokes, chronic obstructive pulmonary disease (COPD), emphysema and cancer. Most cancers caused by smoking are lung cancer, cancer of the larynx, mouth and pancreas. Cigarette smoke also causes heart attacks, peripheral vascular disease and high blood pressure.
In addition to the addictive effects on the central nervous system, cigarette smoke contains a large number of carcinogens. They work by binding to DNA and cause many genetic mutations. Nicotine can be the main cause of DNA binding, causing genetic mutations leading to cancer. It is believed that nicotine disrupts the natural processes of apoptosis (programmed cell death) by binding to DNA in cells (National Institutes of Health (NIH) ). Defective cells consist of unwanted DNA and other waste. When apoptosis is suppressed, there is no natural cell death; instead, defective cells can multiply or grow uncontrollably. This is what happens to cancer, and the main reason that cigarette smokers are more likely to get cancer.
When apoptosis is caused by uncontrolled chemicals such as nicotine, it causes normal cell death. Perhaps this is what happens in the heart tissues of cigarette smokers with heart disease, and may also be what happens in the limbs of cigarette smokers, who often complain of excessive cold fingers, hands, feet and feet. where circulation is weakest.
There is no research to support this accurate claim. However, based on known scientific evidence on apoptosis and the increase in the mortality of cigarette smokers, this hypothetical explanation has some credibility; and we will continue to believe until the guilt is proven! Something deadly happens to cigarette smokers, and nicotine is one of the agents.
Resin in cigarette smoke is also a vital substance for cigarette smokers. A light cigarette smoker is as black as the color of asphalt. It’s like a serious piece of burnt hot. This is why most cigarette smokers find it difficult to breathe. It is almost impossible for air to circulate freely through the airways of smokers. The sad thing is that cigarette smokers find it difficult to quit. So they day after day went on the path of destruction, blowing on a silent killer – a cigarette.
A very important decision to quit smoking – to smoke one cigarette less a day or even one cigarette less per month, if one cigarette a day less – is too much adaptation to the fatal habit. If someone usually smokes a pack of cigarettes a day, they should take out one of these cigarettes and throw it away – throw it in the trash. Remember that the cigarette was lit gradually. At this terrible early stage of smoking, no one started smoking every day on a pack of cigarettes. Smoking one cigarette less over a period of time will help to get rid of unnecessary cholinergic receptors, which are so badly in need of nicotine.
Wellbutrine is another way to help people quit smoking. Wellbutrine is an antidepressant used by people with depression. However, it is very effective in helping people quit the deadly habit of smoking cigarettes. It can be taken while smoking, unlike other means for quitting smoking. Wellbutrine blocks nicotine receptors and weakens the effect of reverse dopamine capture by neurons (J Pharmacol Exp Ther. 2000 Oct; 295 (1): 321-7.).
Cigarette smokers who want to quit should include an exercise program in their schedule, as lack of nicotine leads to weight gain in former cigarette smokers. How would we know that? Former cigarette smokers who quit have complained about weight gain after giving up. Ask any former cigarette smoker. The same will be heard. Nicotine causes weight loss in smokers. This is why most cigarette smokers are thin or thin. If a cigarette smoker gains excess weight while smoking cigarettes, then this person should definitely seek medical help, because in the shade hides a very dangerous disease.